| CYCLOSPORIN - Introduction |
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What is it? Cyclosporin is an immunosuppressant drug developed for the prevention of organ rejection after transplant. It is actually made from a fungus and interferes with the T-cells within the immune system (many research doctors now believe psoriasis is mediated by the T-cells and are looking into targeting the immune system with new generation drug therapies). In psoriasis, Cyclo reduces inflammation and scaling.
Who is it for? Cyclo is prescribed for severe and extensive psoriasis where there is little response from other forms of treatment. It is effective for all types of psoriasis. How is it taken? Cyclo is taken in capsule or solution form and should be taken with water. It is important that no grapefruit juice or grapefruit derivatives are taken alongside the drug as they affect absorption into the bloodstream! How much to I take? Initially, 2.5mg per kg of bodyweight is taken in two equal doses per day and this can be gradually increased to 5mg per kg maximum if no significant improvement is seen within one month. Starting on any higher than 2.5mg per kg can be justified if the severity of the psoriasis requires rapid improvement. However, it is not advisable to take any more than 5mg per kg, particularly if it is to be used long term. You should start to see a result within four to six weeks of taking Cyclo. A normal course of therapy lasts for approximately three to four months, but it can also be used for maintenance or for long term continuous therapy if carefully monitored. What are the side effects and contraindications? The most common side effects of Cyclo are nausea, indigestion, fatigue, high blood pressure, anaemia, headaches, dizziness and, if allergic to the drug, itchiness and swelling of the face, lips and tongue and trouble breathing. It is important that any allergic reaction is reported to a doctor immediately. It is vital that contraception is used whilst on Cyclo as it can affect the unborn child. |
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